尹世金

出生年月：1974年9月

民族：汉族

职称：教授，药学硕士生导师

学科专业：药理学和生药学

研究方向：尹世金，教授，副院长，硕士生导师。2009年获武汉大学微生物学专业博士学位，先后在美国University of Texas Health Science Center at Houston和Washington University in St Louis从事药理学和神经生物学博士后研究工作。主要从事离子通道药理学研究，以疾病相关性离子通道蛋白为靶点，研究生物活性多肽和有机小分子在感觉过敏性反应（痛和痒）及自身免疫性疾病发生中的作用。发现瞬时电位受体通道TRPV1和TRPA1介导类维生素A的痛觉过敏反应；证明人源性Beta防御素2通过直接作用于免疫细胞tlr4受体，诱导细胞因子释放并作用于小鼠背根神经节细胞TRPV1通道而致痒；阐明了Kv1.3通道介导蝎、蜈蚣毒素多肽和傣药龙血竭中查尔酮类化合物的免疫抑制作用。主持国家自然科学基金3项，主持和参与科技部国家重点研发计划等省部级项目10余项；发表研究论文80余篇，其中包括Immunity、Nat Commun和The Journal of Clinical Investigation等自然指数收录的SCI论文40余篇；获国家发明专利4项；获湖北省科学技术进步一等奖、二等奖各一项；获湖北省教学成果二等奖一项；获民族医药协会科技进步一等奖一项。现任中国民族医药协会理事和智库专家、湖北省中医药学会常务理事、湖北省药学会中药和天然药专业委员会委员、湖北省毒理学会理事。独立承担了《生物化学》、《生物化学实验》、《解剖生理学实验》等多门课程的教学工作。

电子邮箱：yinshijinyf@163.com

一、主持和参与的主要省部级研究项目：

1、湖北省自然科学基金创新发展联合基金重点项目，2024AFD262，参芪升免方对膀胱癌生长抑制作用及医院制剂研究，2024/5-2027/5、20万元、在研、主持。

2、国家重点研发计划中医药现代化研究重点专项项目下设一级子项目，2019YFC1712402，经典藏药如意珍宝片和白脉软膏的药效分析与现代药理研究，2019/7-2023/7、107万元、结题、子课题负责人

3、企事业单位委托项目，HZY19025，一种龙血素B衍生物的全合成及其治疗类风湿性关节炎药效评价，2019/08-2022/7、20万元、在研、主持。

4、武汉市国际科技合作计划项目，2017030209020256、Kv1.3通道介导查尔酮类化合物治疗自身免疫疾病的机制、2017/06-2019/12、20万元、结题、主持。

5、湖北省技术创新专项(对外科技合作类)，2017AHB067、传统中药止痒分子机制的国际合作研究、2017/06-2019/12、30万元、在研、参与。

6、国家自然科学基金应急管理项目，81641186、龙血竭中的Kv1.3阻断剂及其自身免疫调节作用、2017/01-2017/12、10万元、已结题、主持。

7、湖北省技术创新专项重大项目，2016ACA138，基于天然产物来源的生物活性化合物库设计生产及应用开发关键技术研究，2016/09-2018/12、100万元、已结题、参与。

8、国家自然科学基金面上项目，81373379、中国蜈蚣目物种多样性调查及药用物种转录组学研究、2014/01-2017/12、70万元、已结题、主持。

9、湖北省自然科学基金面上项目，2015CFB491、龙血竭治疗自身免疫疾病的机制研究、2015.4～2017.4、3万元、已结题、主持。

10、广东省科技厅产学研结合项目，010B090400047、嵌入式无线网络在ICU临床信息系统的应用、2010/10-2013/06、30万元、已结题、主持。

11、国家自然科学青年基金项目，30900239、BmαTX14多肽与通道β亚基协同调节钠通道功能的机制研究、2010/01-2012/12、20万元、已结题、主持。

二、发表的代表性研究论文：

[1]Zhou YS, Tao HB, Lv SS, Liang KQ, Shi WY, Liu KY, Li YY, Chen LY, Zhou L, Yin SJ*, Zhao QR. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. Acta Pharmacol Sin. 2024 Oct;45(10):2045-2060.（SCI1区top，IF8.2，*通讯作者）

[2]Zou Y, Zhao Q, Zhang X, Yu H, Zhou Y, Li Z, Xiao M, Xiang Q, Zhang L, Shi W, Tao H, Chen L, Han B, Yin S*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. Front Immunol. 2023 Apr 24;14:1094649. doi: 10.3389/fimmu.2023.1094649. PMID: 37168850; PMCID: PMC10165104.（SCI2区，IF5.7，*通讯作者）

[3]Zhao Q, Zhang X, Long S, Wang S, Yu H, Zhou Y, Li Y, Xue L, Hu Y, Yin S*. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel. Mol Pharmacol. 2023 Oct;104(4):133-143. doi: 10.1124/molpharm.122.000658. Epub 2023 Jul 7. PMID: 37419692.（SCI2区，IF4.05，*通讯作者）

[4] Qiang Li , Peng Liu, Chen Wu , Lijie Bai , Zhongyun Zhang, Zilu Bao , Min Zou, Zhaoxiang Ren, Lin Yuan, Maochuan Liao, Zhou Lan, Shijin Yin*, Lvyi Chen* . Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia. J Ethnopharmacol. 2022, 298:115679. （SCI2区top，IF5.195，*通讯作者）

[5] Zhang X, Zhao Q, Yang F, Lan Z, Li Y, Xiao M, Yu H, Li Z, Zhou Y, Wu Y, Cao Z, Yin S*. Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58. Mol Pharmacol. 2022,102(3):150-160. （SCI2区，IF4.05，*通讯作者）

[6] Shujuan Shi, Qianru Zhao , Caihua Ke, Siru Long , Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. Frontiers in Pharmacology, 2021, 12:685092.（SCI2区top，IF5.81，*通讯作者）

[7]Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin*, Haohuan Li*. Immunosuppressive Effects of a Novel Potassium Channel Toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019, 9:99。（SCI3区，IF5.03，*通讯作者）

[8]Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Shijin Yin, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS, Hu H. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.Immunity, 2018，49(1):107-119. (SCI1区，IF 19.734,).

[9]Luo J, Bavencoffe A, Yang P, Feng J, Shijin Yin, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H. Zinc inhibits TRPV1 to alleviate chemotherapy-induced neuropathic pain. J Neurosci. 2018, 38(2):474-483. (SCI1区，IF 5.988)

[10] Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Shijin Yin, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol. 2018, 141(2):608-619. (SCI1区，IF 13.06).

[11] Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian Kim, Shijin Yin*, Hongzhen Hu. The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice. Journal of Allergy and Clinical Immunology, 2017, 140(3):885-888. (SCI1区，IF 13.06, *通讯作者).

[12] Zou Y, Zhang F, Li Y, Wang Y, Li Y, Long Z, Shi S, Shuai L, Liu J, Di Z, Shijin Yin*. Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki. Cell & Bioscience. 2017, 7:60.（SCI3区, IF 5.03, *通讯作者).

[13]Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Shijin Yin, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017, 8(1):980. (SCI1区，IF 12.124).

[14] Kim S, Barry DM, Liu XY, Shijin Yin,et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Sci Signal, 2016, 9(437):ra71.(SCI1区, IF 7.359)

[15] Shijin Yin，Yanning Qiu，Zhaohui Pan，Shaobin Li，Zhiyong Di . Chaerilus pseudoconchiformus sp. nov., a new species found in Xizang, and an updated key of the chaerilid scorpions from China (Scorpiones:Chaerilidae)，ZooKeys，2015，495：41-51.（SCI）

[16] Shijin Yin，Yunfeng Zhang，Zhaohui Pan，Shaobin Li，Zhiyong Di ，Scorpiops ingens sp.nov.,found in Xizang, and an updated key of Scorpions from China(Scorpiones:Euscorpidae, Scorpiopinae)，ZooKeys，2015，495：53-61。（SCI）

[17] Kimball C, Luo J, Shijin Yin, Hu H, Dhaka A.The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol, 2015, 88(1):131-8.（SCI, IF 3.931）

[18] Shijin Yin，Qinglan Hu，Jialie Luo，Yuxin Li，Chunlan Lu，XuanChen，Hongzhen Hu. Loureirin B, an essential component of Sanguis Draxonis,inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells，Cell & Bioscience，2014，4：78。（SCI3区, IF 5.03,通讯作者）

[19] Shijin,Yin, Jialie Luo, Aihua Qian, Weihua Yu, Hongzhen Hu. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014,171(6):1510-20 (SCI 2区，IF 5.06, 通讯作者)

[20] Shijin,Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, and Hongzhen Hu. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. The Journal of Clinical Investigation, 2013, 8:1-11 (SCI1区, IF 12.86)

[21] Feng J, Hu Y, Yi H, Shijin Yin, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, Sabatier JM, Li W, Wu Y. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013, 288(18):12544-53. (SCI 2区, IF 5.7)

[22] Dai, Hui¹、Shijin Yin¹、Li, Tian、Cao, Zhijian、Ji, Yonghua、Wu, Yingliang、Li, Wenxin. Recombinant expression, purification, and characterization of scorpion toxin Bm alpha TX14. Protein Expression and Purification, 2012,82(2): 325-331.(SCI, 共同第一作者)

[23] Na Gao, Jialie Luo, Karen Uray, Aihua Qian, Shijin Yin, Guodu Wang, Xiyu Wang, Yun Xia,Jackie D. Wood, Hongzhen Hu. CaMKII Is Essential for the Function of the Enteric Nervous System. PLoS One.2012;7(8):1-10.（SCI, IF 4.351 ）

[24] Chen Z,Hu Y,Han S,Shijin Yin,He Y,Wu Y,Cao Z,Li W. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol.2011 ;25(4):244-51.(SCI)

[25] Song Han¹, Shijin Yin¹, Hong Yi. Ste´phanie Mouhat, Su Qiu, Zhijian Cao, Jean-Marc Sabatier, Yingliang Wu, and Wenxin Li. Protein-Protein Recognition Control by ModulatingElectrostaticInteractions. J Proteome Res, 2010, 9(6):3118-25（SCI 2区, IF 5.684, 共同第一作者）

[26] Di Z., Cao Z, Wu Y.,Shijin Yin., Gregory D and Li W. Discovery of the centipede family Plutoniumidae(Chilopoda) in Asia: a new species of Theatops from China, and the taxonomic value of spiracle distributions in Scolopendromorpha. Zootaxa, 2010, 2667:51-63.（SCI）

[27] Liu, J., Ma, Y., Shijin Yin., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W.,. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus. Peptides, 2009, 30(4):675-80. (SCI)

[28] Shijin Yin., Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI 2区, IF 5.67)

[29] Shijin Yin; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L., Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides, 2008，29（9）: 1514-20. (SCI)

[30] Han, S¹.; Yi, H¹.; Shijin Yin¹.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem , 2008, 283, 19058-19065.(SCI 2区, IF 5.7, 共同第一作者)

[31] Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Shijin Yin.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W., A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci, 2008, 33, 43-46.(SCI)

[32] Wu, W¹.; Shijin Yin¹.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W., Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides, 2007, 28, 2306-2312.（SCI, 共同第一作者）

[33] Yi, H.; Cao, Z.; Shijin Yin.; Dai, C.; Wu, Y.; Li, W., Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6, 611-620. (SCI, IF 5.67)

[34] Mao, X.; Cao, Z.; Shijin Yin.; Ma, Y.; Wu, Y.; Li, W., Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun, 2007, 360, 728-734.(SCI)

[35] Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin Yin.; Yingliang, W.; Wenxin, L., Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides, 2006, 27, 1235-1240. (SCI）

[36] Zhijian, C.; Chao, D.; Shijin Yin.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L., Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol, 2006, 20, 1-6.(SCI)

[37] Wang, K.;Shijin Yin; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett, 2006, 28, 1767-1772.(SCI)

[38] Liu, X.; Shijin Yin.; Chen, S.; Ma, Q., Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc, 2005, 5, 4962-4965.(EI)

[39] Xiangming, L.; Su, C.; Shijin Yin.; Zhinan, M., Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. Sci China C Life Sci, 2004, 47, 340-348.(SCI)

三、发明专利

(1) 龙血竭作为制备防治自身免疫性疾病药物中的应用。2018.6.26，中国发明专利，授权专利号：ZL 2014 1 0565812.0，第一发明人。

(2) 一种龙血素B的衍生物及其制备和应用。2018.7.24,中国发明专利，授权专利号：ZL 2017 1 0519342.8，第一发明人。

(3)一种龙血竭总黄酮的制备方法及应用。2021.09.24，中国发明专利，授权专利号：ZL 2019 1 0150187.6，第一发明人。

(4) 多接入点ZigBee网络协调器。2012，中国实用新型专利，授权专利号：CN 201220123251.5，第二发明人。

(5) 基于无线通信的人体动作检测器。2012，中国实用新型专利，授权专利号：CN 201120446464.7，第二发明人。

(6) 基于ZigBee的无线脉搏检测器。2012，中国实用新型专利，授权专利号：CN 201120446500.X，第二发明人。

(7) 基因工程免疫抑制多肽及制备方法和用途。2009，中国发明专利，授权专利号：CN 101423550B，第五发明人。