出生年月：1987年3月
民族：汉
职称：讲师
学科专业：药物化学/药理学
研究方向：基于天然多糖及其结构片段的创新药物研发
电子邮箱：gn2008.happy@163.com
学习经历：
2013.9-2016.7，中国科学院昆明植物研究所，药物化学，博士
2009.9-2012.6，中南大学，生药学，硕士
2005.9-2009.7，济宁医学院，药物制剂，学士
工作经历：
2016.8--至今，bat365在线平台登录入口，药学院，讲师/硕士研究生导师
2012.7-2013.9，中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，人才助手
研究领域：
主要从事天然产物糖化学及其药理学研究，包括糖类活性成分化学、结构修饰、活性筛选及靶点机制研究。
以第一作者或通讯作者(含共同通讯)在Carbohydr Polym、Eur J Med Chem、Int J Biol Macromol、Thromb Haemost、Arterioscl Throm Vas 等国际期刊发表学术论文二十余篇；作为主要发明人申请并获得中国、美国、日本等国内外授权专利二十余项。
作为核心骨干参加了新靶点抗凝药物LFG53/YB209(内源性凝血因子X酶抑制剂)研发，主要承担药物原料及制剂制备工艺、新药目标成分确认、质量研究、结构确证、杂质研究，并参与构-效关系研究及药代动力学研究、知识产权保护与新药注册等工作。目前，LFG53/YB209已作为First-in-class类新药取得中国NMPA和美国FDA的临床批件(许可)。
主持或参加科研项目：
[1] 国家自然科学基金青年项目，81703374，FG依赖HC-II的抗凝血酶活性的结构序列研究, 2018/01-2020/12，主持
[2] 中央高校基本科研业务青年项目，岩藻糖化糖胺聚糖抑制P/L-选择素及其对炎性肺损伤的保护作用，2023/04-2025/04，主持
[3] 国家自然科学基金面上项目，82073725，基于FG结构片段的P-选择素抑制剂发现及其抗血栓活性研究，2021/01-2024/12，参与
[4] 科学技术部，国家科技重大专项，2017ZX09101003-003-027，抗血栓药物LFG临床前研究，2018/01-2020/12，参与
[5] 中国科学院，中国科学院战略生物资源服务网络计划，ZSTH-020，P-选择素拮抗剂FD-016的血管保护与抗血栓活性评价及其转化研究，2016/09-2018/09，参与
[6] 云南省自然科学基金重点项目，2013FA046，因子X酶抑制剂FGAG衍生物的构效关系及应用价值评价，2013/09-2015/10，参与
学术论文：
1. Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH, Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers. Marine Drugs, 2023, 21, 568.
2. Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH, Gao N*, Zhao JH*. Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate from Phyllophorella kohkutiensis. Carbohydrate Polymers, 2023, 321: 121304.
3. Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Ailainuer R, Gao N*, Zhao JH*. Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota. International Journal of Biological Macromolecules, 2023, 236: 123935.
4. Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H, Gao N*, Zhao JH*. Oligosaccharide blocks PAR1 (proteinase-activated receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, 43: 253-266.
5. Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL*, Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides. Carbohydrate Polymers, 2022, 295: 119855.
6. Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH, Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumber Holothuria fuscopunctata through a bottom up strategy and the antioxidant activity analysis. International Journal of Molecular Sciences, 2022, 23(9): 4488.
7. Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*, Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumber Holothuria floridana and its anticoagulant activity. Marine Drugs, 2022, 20(6): 377.
8. Liu XX, Ning ZM, Zuo ZC, Wang Pin, Yin RH, Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides. Carbohydrate Research, 2022, 511: 108493.
9. Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT, Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization. Carbohydrate Polymers, 2021, 270: 118368.
10. Shi X#, Guan R#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*, Gao N* Zhao JH. Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan from Holothuria floridana. Marine Drugs, 2021, 19: 162.
11. Sun HF#, Gao N#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*. The components and activities analysis of a novel anticoagulant candidate dHG-5. European Journal of Medicinal Chemistry, 2020, 207: 112796.
12. Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata. International Journal of Biological Macromolecules, 2020, 164: 3421–3428.
13. Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK. Liu SB, Yin RH *, Zuo ZL *, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohydrate Polymers, 2019, 224: 115-146.
14. Guan RW#, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX, Gao N*, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan from Apostichopus japonicus: analysis of its depolymerized fragments. Marine Drugs, 2019, 17: 195.
15. Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH, Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides. Marine Drugs, 2020, 18: 286.
16. Zhou LT#, Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk. Thrombosis and Haemostasis, 2020, 120(4): 607-619.
17. Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H, Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. Carbohydrate Polymers, 2020, 233: 115844.
18. Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK, Liu SB, Yin RH*, Zuo ZL*, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohydrate Polymers, 2019, 224: 115146.
19. Xu L#, Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. European Journal of Medicinal Chemistry, 2018, 154: 133-143.
20. Shang FN#, Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. European Journal of Medicinal Chemistry, 2018, 148: 423-435.
21. Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohydrate Polymers, 2015, 127(3): 427–437.
22. Gao N, Wu MY, Liu S, Lian W, Li Z, Zhao JH*. Preparation and characterization of O-acylated fucosylated chondroitin sulfate from sea cucumber. Marine Drugs, 2012, 10: 1647–1661.
主要发明专利：
[1] Zhao JH, Li ZG, Gao N, Wu MY, Chen YM, Zhao LY, Wu YS, Li Z, Xiao C, Zheng SL, Nan ZY, Zhou JB, Xu JP, Zhou LT, Guo YF, Qin HB, Liu JK. Oligosaccharide compound for inhibiting endogenous coagulation factor X-enzyme complex, and preparation method therefor and uses thereof. JP6980018 [日本授权 2021-11-18]
[2] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof. CA2908959 [加拿大授权 2020-10-6]
[3] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. CA2907887 [加拿大授权 2020-10-6]
[4] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. EP2980103 [欧洲授权 2020-11-4]
[5] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L. Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof. IN349399 [印度授权 2020-10-6]
[6] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low molecular weight glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivative thereof. JP 6248179 B2 [日本授权 2017-11-24]
[7] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. US9896517B2 [美国授权 2018-02-20]
[8] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Zi Li Z, Lu F, Xu L, et al. Fuc3S4S substituted oligo-glycosaminoglycan and preparation method thereof. JP6472808 B2 [日本授权 2019-02-01]
[9] 赵金华, 李振国, 高娜, 吴明一, 陈艳明, 赵龙岩, 务勇圣, 李姿, 肖创, 郑顺亮, 南志远, 周剑波, 许建萍, 周路坦, 郭亚芳, 秦红波, 刘吉开. 一种抑制内源性凝血因子X酶复合物的寡糖化合物及其制备方法与用途. ZL201710018307.8 [授权 2021-11-23]
[10] 赵金华, 尹荣华, 高娜, 周路坦, 刘吉开.一种寡糖化合物及其药学上可接受的盐、制备方法及应用. ZL202010410013.1 [授权 2021-10-26]
[11] 何金星, 李姿, 高娜. 一种抗菌组合物、其制备方法及其在抗菌纸制备中的用途. ZL201410077645.5 [授权 2017-12-19]
[12] 赵金华, 何金星, 吴明一, 赵龙岩, 刘峙汶, 杨莲, 李姿, 高娜, 肖创, 徐丽, 陈钧, 周路坦. 一种抑制内源性因子X酶活性的寡糖类化合物及其药物组合物. ZL 201410549676.6 [授权 2017-12-01]
[13] 赵金华, 何金星, 吴明一, 刘峙汶, 高娜, 赵龙岩, 李姿, 卢锋, 徐丽, 肖创, 杨莲, 陈钧, 周路 坦, 彭 文 烈, 刘 吉 开. Fuc3S4S 取 代 的 低 聚 糖 胺 聚 糖 及 其 制 备 方 法. ZL201410007855.7 [授权 2016-08-31]
[14] 赵金华, 吴明一, 高娜, 李姿, 赖森森, 赵龙岩. 一种含末端 2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物. ZL 2013101274 7.0 [授权 2015-11-4]
[15] 赵金华, 刘吉开, 吴明一, 高娜, 卢锋, 李姿. 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用. ZL 2013100 99800.9 [授权 2015-09-16]
