基本信息
出生年月：1990年7月
民族：汉族
邮箱：Qianru.Zhao@scuec.edu.cn
研究方向
神经药理学
以离子通道和受体为靶点的药物作用机制研究
教育及工作经历
2019年8月至今, bat365在线平台登录入口, 药学院, 讲师
2018年7月—2019年6月, 牛津大学, 药理学系，博士后, 合作导师: Peter Somogyi
2013年9月—2018年6月, 复旦大学, 生命科学学院，生物物理及生理学系, 博士, 导师: 梅岩艾
2009年9月—2013年7月, 复旦大学, 生命科学学院，生物科学专业, 学士
科研项目
1. 国家自然科学基金青年项目，32000685，条件敲除大麻素1型受体对海马区篮状神经元可塑性的影响和机制，2021/01-2023/12，24万元，在研，主持
2. 湖北省自然科学基金青年项目，2020CFB348，Neuritin 通过CB1R 对中间神经元可塑性和小鼠记忆能力的作用和机制研究，2020/03-2022/03，5万元，在研，主持
3. 国家自然科学基金海外及港澳学者合作研究基金项目，31428003，Calcineurin-NFATc4参与Neuritin调控神经元Kv4.2表达和兴奋性的分子机制，2015/01-2016/12，20万元，已结题，参与
4. 中华人民共和国科学技术部，国家重点基础研究发展计划（973计划）项目，2011CB503700，电磁辐射危害健康的机理及医学防护的基础研究，2011/01-2015/12，380万元，已结题，参与
代表论文
1. Yongsheng Zhou#, Haobo Tao#, Sisi Lv#, Keqin Liang, Wenyi Shi, Keyi Liu, Yunyun Li, Lvyi Chen, Ling Zhou, Shijin Yin*, Qianru Zhao*. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. 2024. Acta Pharmacologica Sinica. 45(10).
2. Qingyuan Wang#, He-Ping Chen#, Haobo Tao#, Xinyang Li, Qianru Zhao*, Ji-Kai Liu*. Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus Penicillium daleae L3SO. 2024. Organic Letters. 26(36).
3. Yan Zou#, Qianru Zhao#, Xu Zhang, Hui Yu, Yongsheng Zhou, Ziyi Li, Min Xiao, Qiu Xiang, Lirong Zhang, Wenyi Shi, Haobo Tao, Lvyi Chen, Bing Han, Shijin Yin*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. 2023.Frontiers in Immunology. 14:1094649.
4. Shujuan Shi#, Qianru Zhao#, Caihua Ke, Siru Long, Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. 2021. Frontiers in Pharmacology. 12(685092).
5. Junmei Lu, Zhaoyang Li, Qianru Zhao, Dongdong Liu, Yan-Ai Mei*. Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice. 2021. Neurobiology of Disease. 156(105407).
6. Zhao QR*, Lu JM, Li ZY, Mei YA*. Neuritin promotes neurite and spine growth in rat cerebellar granule cells via L-type calcium channel-mediated calcium influx. 2018. Journal of Neurochemistry. 147(1).
7. Jin-jing Yao#, Qian-Ru Zhao#, Dong-Dong Liu, Chi-Wing Chow, and Yan-Ai Mei*. Neuritin Up-regulates KV4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway. 2016. Journal of Biological Chemistry. 291(33).
8. Zhao QR, Lu JM, Yao JJ, Zhang ZY, Ling C, Mei YA*. Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields. 2015. Scientific Reports. 5(11768).
9. He YL, Wang K, Zhao QR, Mei YA*. Cyproheptadine regulates pyramidal neuron excitability in mouse medial prefrontal cortex. 2018. Neuroscience Bulletin. 34(5).
10. Jin-Jing Yao, Qian-Ru Zhao, Jun-Mei Lu, Yan-Ai Mei*. Functions and the related signaling pathways of the neurotrophic factor neuritin. 2017. Acta Pharmacologica Sinica. 39(9).
11. Wang K, Lu JM, Xing ZH, Zhao QR, Hu LQ, Xue L, Zhang J, Mei YA*. Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice. 2017. Scientific Reports. 7(44521).
12. Liu DD, Lu JM, Zhao QR, Hu C, Mei YA*. Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels. 2016. Scientific Reports. Jun 29 (6): 28653.
13.Liu DD, Ren Z, Yang G, Zhao QR, Mei YA*. Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na+ currents through intracellular Ca2+ release. 2014. Journal of Cellular and Molecular Medicine. 305(2).
14. Yao JJ#, Sun J#, Zhao QR, Wang CY, Mei YA*. Neuregulin-1/ErbB4 signaling regulates Kv4.2-mediated transient outward K+ current through the Akt/mTOR pathway. 2013. American Journal of Physiology-Cell Physiology. 18(6).
