fungal infection is a serious infectious disease often encountered in the clinic. The existing antifungal drugs are in great trouble of fungal resistance in clinical use, which makes their efficacy greatly reduced, and it is of great significance to find new drugs that can reverse fungal resistance. Recently, Wang Wenxuan, a teacher of Professor Liu Jikai's team at the School of Pharmacy of the Central South University for nationalities, and others, obtained a novel cell relaxin, c-E. they have novel 6/6/6 ring parallel systems with multiple chiral centers, and their complete structural analysis has some challenges. After their planar structure was determined by one-dimensional, two-dimensional nuclear magnetic field, compounds curtachalasins C and E determined the absolute configuration by single crystal. whereas the chirality of compound curtachalasind (total 0.8 mg) was determined by the calculation of residual dipole coupling (rdc) and ecd. bioactivity tests showed that compound curtacharasinc had a significant resistance reversal activity against fluconazole in candida albicans. At present, antifungal first-line drugs are limited, and the resistance is becoming more and more serious. This study provides a new chemical structure basis for the further development of anti-candida albicans, and has important research value. The results are published in Organic Letters, a prestigious academic journal in the Nature Index (2019,21,1108-1111), linked to https://pubs.acs.org/doi/10.1021/acs.orglett.9b00015. This study was supported by the national natural science foundation, the special project of technological innovation in hubei province (major project) and the central university fund of south central university for nationalities.
