On September 24, Dr. Zhang Lei, Wuhan Institute of Viruses, at the invitation of Professor Lei Xinxiang, School of Pharmacy, came to the school for academic exchange and made an academic report in the 203 lecture hall of the College. The title of the report is "Research and Development of Small Molecular Inhibitors against New Emergent Virus ".
Dr. Zhang Lei introduced the recent research on the mechanism and development of inhibitors of new burst viruses, The development law and harm of new outbreak virus, Ebola virus, Seka virus, fever with thrombocytopenia syndrome were introduced; Having shared the results of screening new coronavirus (SARS-CoV-2) inhibitors, When the new coronavirus enters the host cell, With the help of host cells, The genetic material RNA first translated and expressed two polyprotein precursors (pp1a and pp1ab), After 3 CL of protease and papain, polyprotein precursors undergo intramolecular cleavage, main protease, with master protease Mpro) as a target, A variety of small molecules with virus inhibition were screened. To further explain the X ray crystal structure of carbamofluoride and SARS-CoV-2Mpro, It provides the basis for the development of related drugs; Focused on quantitative proteomics systems research SFTSV and host interactions, The mechanism of SFTSV infection NLRP3 inflammasome, The mechanism of SFTSV pathogenesis starts from the inhibition of SFTSV replication by calcium channel protein antagonists, provide targets for drug screening. He also reported that in January, First, the new strategy of old medicine has made a breakthrough in the screening of anti- SARS-CoV-2.
The report provides new ideas for the students in drug screening. After the meeting, the students and some teachers discussed deeply with Dr. Zhang Lei.
