Cominoglycans, a class of side-chain glycan derivatives that receive wide attention for their special chemical structure and remarkable pharmacological activity.Zhao Jinhua's team of our hospital has been committed to the medicinal chemistry and pharmacology research of such compounds for a long time, and has recently made new progress in cooperation with Professor Liu Jikai, Zuo Zhili, Huang Shengxiong, Qin Hongbo and other teams of Kunming Institute of Botany, Chinese Academy of Sciences, and Zhang Hongbin of Yunnan University.
Based on the purified oligosaccharide strategy, the FG of the plum ginseng source contains the hybrid disaccharide side chain, clarifying the academic questions about the disaccharide side chain in the FG. The exact structure analysis of the source FG further reveals the diversity of the FG diglycoside chain; anticoagulation-effect relationship and antithrombotic activity analysis show that FG sevosaccharide containing the disaccharide side chain can have strong anticoagulant antithrombotic activity.Based on the type of side chain structure, the primary kinetic characteristics of mild acid hydrolysis on the FG side chain, based on the structural analysis of pure oligosaccharide compounds, it first reveals the special terminal structure characteristics of LPS and its possible chemical mechanism.
In low molecular weight FG (LFG), The diverse characteristics of polysaccharides contained in Holothuria fuscopunctata materials are reported, Includes an aminoglycan that has not yet been reported; The pharmacogenic characteristics of ~ 5. multi-component LFG drugs as endogenous factor X enzyme inhibitor of 5.3 k D a were analyzed from the perspective of structure-effect relationship and pharmaceutical research; The chemical structure of the oligosaccharides containing LFG, the activity intensity of iXase inhibition and its target selectivity, selective inhibition of endogenous coagulation, and low bleeding antithrombotic activity were systematically analyzed, The correlation between LFG anticoagulant antithrombotic activity and chemical composition was clearly revealed by a mathematical model.
FG-related pharmacological activity studies also found that FG and its derivatives had significant inhibitory activity against acetylheparanase associated with angiogenesis and tumor invasion, and significantly inhibited tumor-related neoangiogenesis as well as tumor cell metastasis.
The first authors of the paper include Gao Na, Yin Ronghua, Liu Xixi, Zhou Lutan, Sun Huifang, Mao Hui, Cai Ying and Li Xiaomei, and the research is funded by the National Natural Science Foundation and other projects.
